A system for removing charged particles from the brain in which a cannula with a distal anode, a proximal cathode and a vacuum are used. The cannula also comprises a fluid delivery port that is functionally connected to a vacuum, and holes with the distal end of the cannula. The charged species in the brain tissue are drawn to the anode that is on the distal end of the probe, when a cathode is placed on the skull of the patient and an appropriate electric field is applied between the anode and cathode. The use of a vacuum within the device to remove the destructive charged particles.