A multichannel pipette, including a grip part defining a longitudinal axis and including a piston-driving device movable axially thereon, a displacement part rotating about the axis and having cylinder and piston arrangements, and a connection device for detachably connecting the grip part to the displacement part and permitting a rotation of the displacement about the longitudinal axis. The connection device includes threaded connection elements engaged with one another. The pistons move axially to the cylinders via a piston-driving device. A connection part of the threaded elements is axially connected with the cylinders and includes a clearance for a rotary bearing provided therein. Form-fit configurations on the support and connection parts are engaged to prevent a reverse rotation of the connection part relative to the support part. By a manual release action, the form-fit configurations disengage, such that the connection part rotates in a reverse rotation relative to the support part.