Invention Grant
- Patent Title: Biosensor electrode mediators for regeneration of cofactors
- Patent Title (中): 用于再生辅因子的生物传感器电极介质
-
Application No.: US11849790Application Date: 2007-09-04
-
Publication No.: US08012341B2Publication Date: 2011-09-06
- Inventor: Nigel J. Forrow , Gurdial S. Sanghera , Jared L. Watkin , Stephen Walters
- Applicant: Nigel J. Forrow , Gurdial S. Sanghera , Jared L. Watkin , Stephen Walters
- Applicant Address: US CA Alameda
- Assignee: Abbott Laboratories
- Current Assignee: Abbott Laboratories
- Current Assignee Address: US CA Alameda
- Agency: Bozicevic, Field & Francis, LLP
- Agent Edward J. Baba; Khin K. Chin
- Main IPC: G01N27/327
- IPC: G01N27/327

Abstract:
The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
Public/Granted literature
- US20070289881A1 BIOSENSOR ELECTRODE MEDIATORS FOR REGENERATION OF COFACTORS Public/Granted day:2007-12-20
Information query