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US08012341B2 Biosensor electrode mediators for regeneration of cofactors 有权
用于再生辅因子的生物传感器电极介质

Biosensor electrode mediators for regeneration of cofactors
Abstract:
The present invention is based on the discovery of NAD+ and NADP+ mediator compounds that do not bind irreversibly to thiol groups in the active sites of intracellular dehydrogenase enzymes. Such mediator compounds avoid a common mode of enzyme inhibition. The mediators can therefore increase the stability and reliability of the electrical response in amperometric electrodes constructed from NAD- or NADP-dependent enzymes.
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