Invention Grant
- Patent Title: Drug conjugate composition
- Patent Title (中): 药物缀合物组成
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Application No.: US12366830Application Date: 2009-02-06
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Publication No.: US08012485B2Publication Date: 2011-09-06
- Inventor: Godfrey Amphlett , Wei Zhang , Michael Fleming
- Applicant: Godfrey Amphlett , Wei Zhang , Michael Fleming
- Applicant Address: US MA Waltham
- Assignee: ImmunoGen, Inc.
- Current Assignee: ImmunoGen, Inc.
- Current Assignee Address: US MA Waltham
- Agency: Leydig, Voit & Mayer, Ltd.
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K39/44 ; C07K19/00 ; C07K16/28 ; C07K16/30

Abstract:
The invention provides a lyophilized composition comprising a therapeutically effective amount of a conjugate comprising an antibody chemically coupled to a maytansinoid. The invention further provides a method for killing a cell in a human comprising administering to the human the reconstituted composition such that the antibody binds to the surface of the cell and the cytotoxicity of the maytansinoid is activated, whereby the cell is killed.
Public/Granted literature
- US20090142361A1 DRUG CONJUGATE COMPOSITION Public/Granted day:2009-06-04
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