Invention Grant
- Patent Title: Gastric retention controlled drug delivery system
- Patent Title (中): 胃滞留控制药物输送系统
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Application No.: US12856097Application Date: 2010-08-13
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Publication No.: US08012496B2Publication Date: 2011-09-06
- Inventor: Kamlesh Mohanlal Dudhara , Nitin Bhalachandra Dharmadhikari , Vaishali Vijay Dhavse
- Applicant: Kamlesh Mohanlal Dudhara , Nitin Bhalachandra Dharmadhikari , Vaishali Vijay Dhavse
- Applicant Address: IN Andheri
- Assignee: Sun Pharma Advanced Research Company Ltd.
- Current Assignee: Sun Pharma Advanced Research Company Ltd.
- Current Assignee Address: IN Andheri
- Agency: Sughrue Mion, PLLC
- Priority: IN612/MUM/2001 20010704
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K9/24 ; A61K31/195 ; A61P7/00

Abstract:
The present invention provides a gastric retention controlled drug delivery system comprising: (a) a controlled release core comprising a drug, a highly swellable polymer and a gas generating agent, said core being capable of swelling and achieving floatation rapidly while maintaining its physical integrity in gastrointestinal fluids for prolonged periods, and (b) a rapidly releasing coat composition comprising the same drug as in the core and pharmaceutically acceptable excipients, wherein the coating composition surrounds the core such that the system provides a biphasic release of the drug in gastrointestinal fluids.
Public/Granted literature
- US20100305208A1 GASTRIC RETENTION CONTROLLED DRUG DELIVERY SYSTEM Public/Granted day:2010-12-02
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