The invention refers to coatings on different substrates, whereby a hydrophilic polymer layer is bound by means of a polymer adhesion promoter layer to a substrate. A method for the production of these layer systems is disclosed as well. The layers according to the invention can be used as immobilization matrix and for the suppression of non-specific protein adsorption in biosensors, MALDI targets and other bioanalytical devices. Furthermore they can be used for the bio-compatibilization of implants and for the coating of contact lenses. Optical elements, which are provided with such coatings, do not fog up any more. Beyond that the layers are dirt-deflecting and/or self-cleaning.