Invention Grant
US08012711B2 Methods of screening for compounds that reduce microbial resistance to fluoroquinolones
有权
筛选降低微生物对氟喹诺酮类抗性的化合物的方法
- Patent Title: Methods of screening for compounds that reduce microbial resistance to fluoroquinolones
- Patent Title (中): 筛选降低微生物对氟喹诺酮类抗性的化合物的方法
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Application No.: US12476053Application Date: 2009-06-01
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Publication No.: US08012711B2Publication Date: 2011-09-06
- Inventor: Margret Oethinger , Stuart B. Levy
- Applicant: Margret Oethinger , Stuart B. Levy
- Applicant Address: US MA Medford
- Assignee: Trustees of Tufts College
- Current Assignee: Trustees of Tufts College
- Current Assignee Address: US MA Medford
- Agency: McCarter & English, LLP
- Agent Elizabeth A. Hanley; Colleen J. McKiernan
- Main IPC: C12Q1/18
- IPC: C12Q1/18
Abstract:
The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of screening for inhibitors of AcrAB-like efflux pumps, and methods of enhancing antimicrobial activity of drugs are provided. Pharmaceutical composition comprising an inhibitor of an AcrAB-like efflux pump and an antimicrobial agent are also provided.
Public/Granted literature
- US20090298873A1 METHODS OF REDUCING MICROBIAL RESISTANCE TO DRUGS Public/Granted day:2009-12-03
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