Invention Grant
US08012735B2 Infectious cDNA clone of the modified live virus vaccine strain of Equine arteritis virus
有权
马动脉炎病毒改良活病毒疫苗株的感染性cDNA克隆
- Patent Title: Infectious cDNA clone of the modified live virus vaccine strain of Equine arteritis virus
- Patent Title (中): 马动脉炎病毒改良活病毒疫苗株的感染性cDNA克隆
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Application No.: US12436242Application Date: 2009-05-06
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Publication No.: US08012735B2Publication Date: 2011-09-06
- Inventor: Udeni B. R. Balasuriya , Peter J. Timoney , Jianqiang Zhang
- Applicant: Udeni B. R. Balasuriya , Peter J. Timoney , Jianqiang Zhang
- Applicant Address: US KY Lexington
- Assignee: University of Kentucky Research Foundation
- Current Assignee: University of Kentucky Research Foundation
- Current Assignee Address: US KY Lexington
- Agency: King & Schickli, PLLC
- Main IPC: C12N7/00
- IPC: C12N7/00 ; C12N15/63 ; C12N15/85
Abstract:
An isolated polynucleotide molecule includes a DNA sequence encoding an infectious RNA molecule encoding a modified live viral strain of an Equine arteritis virus, wherein the DNA sequence is SEQ ID NO:1 or a degenerate variant thereof. Also provided are transformed or transfected host cells including that sequence, vectors including the sequence, and isolated infectious RNA molecules encoded by the sequence. Further, a modified DNA sequence encoding an infectious RNA molecule encoding a modified live viral strain of an Equine arteritis virus is provided wherein the DNA sequence is SEQ ID NO:2 or a degenerate variant thereof, including a silent point mutation allowing distinguishing the modified sequence from the parent and other strains of Equine arteritis virus.
Public/Granted literature
- US20100221826A1 INFECTIOUS cDNA CLONE OF THE MODIFIED LIVE VIRUS VACCINE STRAIN OF EQUINE ARTERITIS VIRUS Public/Granted day:2010-09-02
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