Invention Grant
US08012925B2 Agent for inducing apoptosis comprising MSX1 or a gene encoding the same as an active ingredient
有权
用于诱导凋亡的药剂，其包含MSX1或编码其作为活性成分的基因
- Patent Title: Agent for inducing apoptosis comprising MSX1 or a gene encoding the same as an active ingredient
- Patent Title (中): 用于诱导凋亡的药剂，其包含MSX1或编码其作为活性成分的基因
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Application No.: US12343104Application Date: 2008-12-23
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Publication No.: US08012925B2Publication Date: 2011-09-06
- Inventor: Je-Ho Lee , Kyoungsook Park
- Applicant: Je-Ho Lee , Kyoungsook Park
- Applicant Address: KR
- Assignee: Sungkyunkwan University Foundation for Corporate Collaboration
- Current Assignee: Sungkyunkwan University Foundation for Corporate Collaboration
- Current Assignee Address: KR
- Agency: Sheridan Ross P.C.
- Priority: KR10-2005-66541 20050722
- Main IPC: A01N37/18
- IPC: A01N37/18
Abstract:
The present invention relates to a novel use of Msx1 protein or a nucleotide encoding the same for inducing apoptosis. The Msx1 of the present invention induces apoptosis through direct interaction with p53 via a homeodomain and such interaction leads to increased stability, and/or nuclear localization of p53 in cells. The Msx1 or homeodomain thereof can be effectively used for the treatment of tumors, in which wild-type p53 protein has lost its function by some mechanism that inactivates p53 proteins.
Public/Granted literature
- US20100016222A1 NOVEL AGENT FOR INDUCING APOPTOSIS COMPRISING MSX1 OR A GENE ENCODING THE SAME AS AN ACTIVE INGREDIENT Public/Granted day:2010-01-21
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