Invention Grant
US08012933B2 Use of the cathelicidin LL-37 and derivatives therof for wound healing
有权
使用导管素LL-37和衍生物用于伤口愈合
- Patent Title: Use of the cathelicidin LL-37 and derivatives therof for wound healing
- Patent Title (中): 使用导管素LL-37和衍生物用于伤口愈合
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Application No.: US12232215Application Date: 2008-09-12
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Publication No.: US08012933B2Publication Date: 2011-09-06
- Inventor: Mona Ståhle-Bäckdahl , Johan Heilborn , Anders Carlsson , Conny Bogentoft
- Applicant: Mona Ståhle-Bäckdahl , Johan Heilborn , Anders Carlsson , Conny Bogentoft
- Applicant Address: SE Stockholm
- Assignee: Lipopeptide AB
- Current Assignee: Lipopeptide AB
- Current Assignee Address: SE Stockholm
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: SE0300207 20030129
- Main IPC: A61K38/16
- IPC: A61K38/16 ; C07K14/00 ; C07K14/47 ; A61P17/02 ; A61P35/00 ; C12N5/00 ; C12N15/09
Abstract:
Use of the antimicrobial cathelicidin peptide II-37, N-terminal fragments of LL-37 or extended sequences of LL-37 having 1-3 amino acids in the C-terminal end, for stimulating proliferation of epithelial and stromal cells and thereby healing of wounds, such as chronic ulcers. The cytotoxic effect of LL-37 may be reduced by including a bilayer-forming polar lipid, especially a digalactosyldiacylglycerol, in pharmaceutical compositions and growth media comprising LL-37.
Public/Granted literature
- US20090088382A1 Use of the cathelicidin LL-37 and derivatives therof for wound healing Public/Granted day:2009-04-02
Information query
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