Invention Grant
US08012937B2 Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer 有权
核酸和相应的蛋白质98P4B6可用于治疗和检测癌症

Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer
Abstract:
A novel gene 098P4B6 (also designated STEAP-2) and its encoded protein, and variants thereof, are described wherein 98P4B6 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 98P4B6 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 98P4B6 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 98P4B6 can be used in active or passive immunization.
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