Invention Grant
US08012968B2 Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof
有权
具有脯氨酰羟化酶抑制活性的喹诺酮类化合物及其组合物及其用途
- Patent Title: Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof
- Patent Title (中): 具有脯氨酰羟化酶抑制活性的喹诺酮类化合物及其组合物及其用途
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Application No.: US12703716Application Date: 2010-02-10
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Publication No.: US08012968B2Publication Date: 2011-09-06
- Inventor: Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael J. Frohn , Jennifer E. Golden , Randall W. Hungate , Robert Kurzeja , Stephanie J. Mercede , Kristine M. Muller , Susana C. Neira , Tanya A. N. Peterkin , Christopher M. Tegley , Violeta Yu
- Applicant: Jennifer R. Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael J. Frohn , Jennifer E. Golden , Randall W. Hungate , Robert Kurzeja , Stephanie J. Mercede , Kristine M. Muller , Susana C. Neira , Tanya A. N. Peterkin , Christopher M. Tegley , Violeta Yu
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Agent Jones Day
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/501 ; A61K31/506 ; A61K31/4704
Abstract:
This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.
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