Invention Grant
US08012989B2 Substituted pyrimidine compounds and their utility as CETP inhibitors
有权
取代的嘧啶化合物及其作为CETP抑制剂的用途
- Patent Title: Substituted pyrimidine compounds and their utility as CETP inhibitors
- Patent Title (中): 取代的嘧啶化合物及其作为CETP抑制剂的用途
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Application No.: US12815905Application Date: 2010-06-15
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Publication No.: US08012989B2Publication Date: 2011-09-06
- Inventor: Tadaaki Ohgiya , Toru Miura , Ayumu Okuda , Toshiharu Arai , Koichi Yamazaki , Taro Aoki , Katsutoshi Miyosawa , Haruki Shibata , Kimiyuki Shibuya
- Applicant: Tadaaki Ohgiya , Toru Miura , Ayumu Okuda , Toshiharu Arai , Koichi Yamazaki , Taro Aoki , Katsutoshi Miyosawa , Haruki Shibata , Kimiyuki Shibuya
- Applicant Address: JP Nagoya-shi
- Assignee: Kowa Company, Ltd.
- Current Assignee: Kowa Company, Ltd.
- Current Assignee Address: JP Nagoya-shi
- Agency: Greenblum & Bernstein, P.L.C.
- Main IPC: A61K31/505
- IPC: A61K31/505

Abstract:
A compound represented by the following general formula (I), wherein R1, R2, R3, R4 and R5 represent hydrogen atom, a halogen atom, a lower alkyl group and the like, R6 represents an alkyl group, a cycloalkyl group and the like, R7 and R8 represent hydrogen atom, a lower alkyl group, a (lower cycloalkyl)(lower alkyl) group and the like, R9 represents hydrogen atom, a halogen atom, a lower alkoxy group and the like, R10 and R11 represent hydrogen atom, a lower alkyl group, a lower alkoxy group, a halo(lower alkyl) group and the like, and A represents a heterocyclic ring constituted by 6 to 10 atoms, which has potent inhibitory activity on cholesterol ester transfer protein (CETP).
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