- Patent Title: Methods of converting a patient's treatment regimen from intravenous administration of an opioid to oral co-administration of morphine and oxycodone using a dosing algorithm to provide analgesia
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Application No.: US12881728Application Date: 2010-09-14
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Publication No.: US08012990B2Publication Date: 2011-09-06
- Inventor: Patricia T. Richards , Warren C. Stern , Laurel J. Mengle-Gaw , Benjamin D. Schwartz
- Applicant: Patricia T. Richards , Warren C. Stern , Laurel J. Mengle-Gaw , Benjamin D. Schwartz
- Applicant Address: US NJ Bedminster
- Assignee: QRxPharma Ltd.
- Current Assignee: QRxPharma Ltd.
- Current Assignee Address: US NJ Bedminster
- Agency: Frommer Lawrence & Haug LLP
- Agent Sandra Kuzmich; Russell A. Garman
- Main IPC: A01N43/42
- IPC: A01N43/42 ; A01N43/38 ; A01N37/10 ; A61K31/44 ; A61K31/40 ; A61K9/28 ; A61K9/20 ; C07D489/00 ; A61K31/19
Abstract:
A method of converting a treatment for pain comprising intravenous administration of opioids, to a treatment for pain comprising oral administration of a first dose of an immediate release morphine-oxycodone combination in patients in need of analgesia. The method may comprise (1) determining a four-hour average oral morphine equivalents or determining a net average hourly intravenous dose, and (2) orally administering to the patient a first dose of a morphine-oxycodone combination in a 3:2 ratio by weight every four to six hours. Also, a method of treating pain in patients who had been administered opioids intravenously, comprising using a dosing algorithm to determine the first dose of the immediate release morphine-oxycodone combination.
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