Invention Grant
US08012992B2 Aza-indoles and related compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
有权
氮杂 - 吲哚和具有鞘氨醇-1-磷酸（S1P）受体拮抗剂生物活性的相关化合物
- Patent Title: Aza-indoles and related compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity
- Patent Title (中): 氮杂 - 吲哚和具有鞘氨醇-1-磷酸（S1P）受体拮抗剂生物活性的相关化合物
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Application No.: US12493463Application Date: 2009-06-29
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Publication No.: US08012992B2Publication Date: 2011-09-06
- Inventor: Haiqing Yuan
- Applicant: Haiqing Yuan
- Applicant Address: US CA Irvine
- Assignee: Allergan, Inc.
- Current Assignee: Allergan, Inc.
- Current Assignee Address: US CA Irvine
- Agent Doina G. Ene; John E. Wurst; Kevin J. Forrestal
- Main IPC: C07D471/02
- IPC: C07D471/02 ; C07D491/02 ; C07D513/02 ; C07D515/02 ; A61K31/44
Abstract:
The present invention provides compounds are disclosed herein having the formula: Wherein n is 1 or 2; m is 0 or 1; p is 0, 1 or 2; R1 is aryl, heteroaryl or alkyl; R2 is C1-6 hydrocarbyl, alkylacyl or hydroxyalkyl; R3 is aryl, heteroaryl, or alkyl; R4 is H, OH, —O—(C1-6 alkyl), —NH—(C1-6 alkyl), or oxide; R5 is H, halogen, C1-6 alkyl, O—(C1-6 alkyl), aryl, heteroaryl, —C(═O)(C1-6 alkyl), substituted or un-substituted oxazolin-2-yl; X═O, NH, —C(═O)— or —N═CH—; and Each L is independently alkylene and carbonyl. Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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