Invention Grant
US08013163B2 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide acid addition salts as kinase inhibitors
有权
4-（2,6-二氯 - 苯甲酰氨基）-1H-吡唑-3-羧酸哌啶-4-基酰胺酸加成盐作为激酶抑制剂
- Patent Title: 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide acid addition salts as kinase inhibitors
- Patent Title (中): 4-（2,6-二氯 - 苯甲酰氨基）-1H-吡唑-3-羧酸哌啶-4-基酰胺酸加成盐作为激酶抑制剂
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Application No.: US11814458Application Date: 2006-01-20
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Publication No.: US08013163B2Publication Date: 2011-09-06
- Inventor: Paul Graham Wyatt , David Charles Rees , Mladen Vinkovic , Gary Trewartha
- Applicant: Paul Graham Wyatt , David Charles Rees , Mladen Vinkovic , Gary Trewartha
- Applicant Address: GB Cambridge
- Assignee: Astex Therapeutics Limited
- Current Assignee: Astex Therapeutics Limited
- Current Assignee Address: GB Cambridge
- Agency: Heslin Rothenberg Farley & Mesiti P.C.
- Priority: GB0501475.8 20050122
- International Application: PCT/GB2006/000207 WO 20060120
- International Announcement: WO2006/077426 WO 20060727
- Main IPC: C07D401/00
- IPC: C07D401/00 ; A61K31/445
Abstract:
The invention provides an acid addition salt of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and crystals thereof, the salt being formed with an acid selected from methanesulphonic acid and acetic acid and mixtures thereof. Also provided are the novel uses of salts of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide, processes for the preparation of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and its salts and novel chemical intermediates.
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