Invention Grant
US08013170B2 Substituted pyrrolo[1,2-d][1,4]-diazonines and treatment of brain damage
有权
取代的吡咯并[1,2-d] [1,4] - 二氮嗪并治疗脑损伤
![Substituted pyrrolo[1,2-d][1,4]-diazonines and treatment of brain damage](/docs/US/2011-09-06/US08013170B2/abs.jpg.600x600.jpg)
- Patent Title: Substituted pyrrolo[1,2-d][1,4]-diazonines and treatment of brain damage
- Patent Title (中): 取代的吡咯并[1,2-d] [1,4] - 二氮嗪并治疗脑损伤
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Application No.: US12002178Application Date: 2007-12-14
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Publication No.: US08013170B2Publication Date: 2011-09-06
- Inventor: Paul William Richard Harris , Margaret Anne Brimble
- Applicant: Paul William Richard Harris , Margaret Anne Brimble
- Agency: Borson Law Group PC
- Agent D. Benjamin Borson
- Main IPC: C07D487/02
- IPC: C07D487/02 ; C07D491/02 ; C07D495/02 ; C07D497/02
![Substituted pyrrolo[1,2-d][1,4]-diazonines and treatment of brain damage](/abs-image/US/2011/09/06/US08013170B2/abs.jpg.150x150.jpg)
Abstract:
Embodiments of this invention provide novel peptidomimetics that contain a macrocycle, an embodiment of which is 2S,9′S,12′S)-2-{[(1′,4′-Diaza-2′-oxobicyclo[7.3.0]dodecyl)-12′-carbonyl]amino}-1,5-pentanedioic acid trifluoroacetate. Such compounds are neuroprotective and have utility as therapeutic agents for treatment of diseases, injuries and other conditions characterized by neuronal degeneration and/or neuronal cell death caused by in embodiments, toxicity or hypoxia. Compounds are also useful for manufacture of medicaments useful for treatment of such conditions.
Public/Granted literature
- US20110052528A1 Neuroprotective macrocyclic compounds and methods for their use Public/Granted day:2011-03-03
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