Multiple-Input-Single-Output (MISO) amplification and associated VPA control algorithms are provided herein. According to embodiments of the present invention, MISO amplifiers driven by VPA control algorithms outperform conventional outphasing amplifiers, including cascades of separate branch amplifiers using conventional power combiner technologies. MISO amplifiers can be operated at enhanced efficiencies over the entire output power dynamic range by blending the control of the power source, source impedances, bias levels, outphasing, and branch amplitudes. These blending constituents are combined to provide an optimized transfer characteristic function.