Selection circuitry for use in register files, multiplexers, and so forth is disclosed. The selection circuitry includes a plurality of local bit lines coupled to global bit line circuitry. Groups of cells or data inputs are coupled to each of the local bit lines. When a cell or data input of a given group is selected, a group select signal is provided to the global bit line circuitry. The global bit line circuitry drives a global bit line responsive to the group select signal and the data driven on (or provided to) the local bit line associated with the selected cell/input, thus providing a data output. When no cell of a given group is selected, the group select signal is de-asserted, causing the respective global bit line to be held in a predetermined state.