Methods and systems for utilizing a single PLL to clock an array of DDFS for multi-protocol applications are disclosed. Aspects of one method may include generating a first signal for use in generating a plurality of local oscillator (LO) signals. The first signal may be communicated to a plurality of LO generators. Each of the LO signals may be generated independently of each other by a corresponding one of the LO generators. Each of the LO signals may be communicated to one or more mixers, where each mixer may perform down-conversion or up-conversion. A LO generator may utilize, for example, a DDFS or a digital delay circuit. A frequency of a LO signal may be varied by adjusting a divide factor for a divider that generates a reference clock for the DDFS or for a divider that generates a second signal used for mixing with a signal generated by the DDFS. The LO signal frequency may also be varied by adjusting frequency control words received by a DDFS.