Invention Grant
US08014954B2 Methods for characterizing agonists and partial agonists of target molecules
有权
表征目标分子的激动剂和部分激动剂的方法
- Patent Title: Methods for characterizing agonists and partial agonists of target molecules
- Patent Title (中): 表征目标分子的激动剂和部分激动剂的方法
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Application No.: US11397327Application Date: 2006-04-04
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Publication No.: US08014954B2Publication Date: 2011-09-06
- Inventor: Yejun Tan , Hongyue Dai , Pek Yee Lum , John Ryan Thompson , Joel Peter Berger , Eric Stanley Muise , Richard F Raubertas , Kenny Kin Chung Wong
- Applicant: Yejun Tan , Hongyue Dai , Pek Yee Lum , John Ryan Thompson , Joel Peter Berger , Eric Stanley Muise , Richard F Raubertas , Kenny Kin Chung Wong
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agency: Christensen O'Connor Johnson Kindness PLLC
- Main IPC: G01N33/48
- IPC: G01N33/48 ; C12Q1/68 ; G06G7/58
Abstract:
In one aspect, the present invention provides methods of determining whether an agent is more like a partial agonist of a target molecule than a full agonist of the same target molecule. In another aspect, the present invention provides methods to select a candidate compound that may reduce blood plasma glucose concentration in a mammal. Populations of genes are provided that are useful in the practice of the present invention.
Public/Granted literature
- US20060240457A1 Methods for characterizing agonists and partial agonists of target molecules Public/Granted day:2006-10-26
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