A voice control system includes an acoustic sensor, and a digital photo frame. The acoustic sensor is configured to receive a voice signal, and transform the voice signal to an electronic signal. The digital photo frame includes a transforming module, an instruction module, and a comparing module. The transforming module receives the electronic signal sent from the acoustic sensor and transforms the electronic signal to a transformed electronic code. The instruction module defines a plurality of predetermined electronic codes for performing predetermined functions of the digital photo frame. The comparing module compares the transformed electronic code with the predetermined electronic codes. If the transformed electronic code matches one of the predetermined electronic codes, the digital photo frame performs a function of the predetermined functions associated with the matched predetermined electronic code. A method for operating the digital photo frame is also provided.