A wake-and-go mechanism is configured to issue a look-ahead load command on a system bus to read a data value from a target address and perform a comparison operation to determine whether the data value at the target address indicates that an event for which a thread is waiting has occurred. In response to the comparison resulting in a determination that the event has not occurred, the wake-and-go engine populates the wake-and-go storage array with the target address. In response to the comparison resulting in a determination that the event has occurred, the wake-and-go engine issues a load command on the system bus to read the data value from the target address with data exclusivity and determines whether the wake-and-go engine obtains a lock for the target address. Responsive to obtaining the lock for the target address, the wake-and-go engine holds the lock for the thread.