Invention Grant
- Patent Title: Endosomolytic poly(acrylate) polymers
- Patent Title (中): 内分解聚（丙烯酸酯）聚合物
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Application No.: US12140703Application Date: 2008-06-17
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Publication No.: US08017109B2Publication Date: 2011-09-13
- Inventor: Darren H. Wakefield , David B. Rozema , Sean D. Monahan , Lori Higgs , Jon A. Wolff , James E. Hagstrom
- Applicant: Darren H. Wakefield , David B. Rozema , Sean D. Monahan , Lori Higgs , Jon A. Wolff , James E. Hagstrom
- Applicant Address: US WI Madison
- Assignee: Roche Madison Inc.
- Current Assignee: Roche Madison Inc.
- Current Assignee Address: US WI Madison
- Agent Kirk Ekena
- Main IPC: A61K31/74
- IPC: A61K31/74
Abstract:
The present invention is directed to membrane active polymers useful for cellular delivery of compounds. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery conjugates. The use of reversible modification provides for physiologically responsive activity modulation.
Public/Granted literature
- US20080287630A1 Endosomolytic Poly(Acrylate) Polymers Public/Granted day:2008-11-20
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