Invention Grant
US08017350B2 Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C regulation
有权
格列美脲和胰岛素诱导的糖基磷脂酰肌醇特异性磷脂酶C调节
- Patent Title: Glimepiride- and insulin-induced glycosylphosphatidylinositol-specific phospholipase C regulation
- Patent Title (中): 格列美脲和胰岛素诱导的糖基磷脂酰肌醇特异性磷脂酶C调节
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Application No.: US11464245Application Date: 2006-08-14
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Publication No.: US08017350B2Publication Date: 2011-09-13
- Inventor: Guenter Mueller , Wendelin Frick , Rudolf Schneider
- Applicant: Guenter Mueller , Wendelin Frick , Rudolf Schneider
- Applicant Address: DE Frankfurt am Main
- Assignee: Sanofi-Aventis Deutschland GmbH
- Current Assignee: Sanofi-Aventis Deutschland GmbH
- Current Assignee Address: DE Frankfurt am Main
- Agent J. Darrell Fontenot
- Priority: EP04003897 20040220
- Main IPC: C12Q1/00
- IPC: C12Q1/00 ; C12Q1/34
Abstract:
The present invention relates to a method for identification of a chemical compound which modulates the activity of mammalian GPI-PLC whereina] a mammalian cell is incubated with glimepiride;b] hcDIGs of the cells of a] are prepared;c] the hcDIGs from b] are incubated with a chemical compound;d] the activity of the GPI-PLC from the hcDIGs of c] is determined.
Public/Granted literature
- US20070111263A1 GLIMEPIRIDE- AND INSULIN-INDUCED GLYCOSYLPHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C REGULATION Public/Granted day:2007-05-17
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