Invention Grant
- Patent Title: Peptides derived from human BPLP protein
- Patent Title (中): 衍生自人BPLP蛋白的肽
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Application No.: US10593071Application Date: 2005-03-18
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Publication No.: US08017571B2Publication Date: 2011-09-13
- Inventor: Catherine Rougeot , Jean-Francois Huaulme , Marie-Noelle Ungeheuer , Anne Wisner , Evelyne Dufour
- Applicant: Catherine Rougeot , Jean-Francois Huaulme , Marie-Noelle Ungeheuer , Anne Wisner , Evelyne Dufour
- Applicant Address: FR Paris
- Assignee: Institut Pasteur
- Current Assignee: Institut Pasteur
- Current Assignee Address: FR Paris
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: EP04290754 20040319
- International Application: PCT/IB2005/000700 WO 20050318
- International Announcement: WO2005/090386 WO 20050929
- Main IPC: A61K38/04
- IPC: A61K38/04
Abstract:
The invention relates to a peptide that is a maturation product of the Basic Prolin-rich Lacrinal Protein (BPLP) or a peptide derivative of said maturation product, wherein the peptide or peptide derivative exhibits an inhibitory property against a metallo-ectopeptidase, especially NEP and/or APN.The present invention also relates to polynucleotides coding for said peptides and to antibodies directed against said peptides. Furthermore, the present invention relates to diagnostic and therapeutic uses of human BPLP protein and inhibitory peptides derived therefrom, polypeptides coding for human BPLP protein or peptides derived therefrom as well as antibodies directed against BPLP protein or peptides derived therefrom.
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