Invention Grant
US08017593B2 Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis
有权
可用于调节血管发生的色氨酰-tRNA合成酶衍生的多肽
- Patent Title: Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis
- Patent Title (中): 可用于调节血管发生的色氨酰-tRNA合成酶衍生的多肽
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Application No.: US12319822Application Date: 2009-01-13
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Publication No.: US08017593B2Publication Date: 2011-09-13
- Inventor: Paul Schimmel , Keisuke Wakasugi , Martin Friedlander
- Applicant: Paul Schimmel , Keisuke Wakasugi , Martin Friedlander
- Applicant Address: US CA La Jolla
- Assignee: The Scripps Research Institute
- Current Assignee: The Scripps Research Institute
- Current Assignee Address: US CA La Jolla
- Agency: Olson & Cepuritis, Ltd.
- Main IPC: A61K48/00
- IPC: A61K48/00
Abstract:
The invention provides a method for inhibiting ocular neovascularization in a patient. The method comprises administering to a patient an ocular neovascularization inhibiting amount of a water-soluble polypeptide selected from the group consisting of SEQ ID NO: 12, SEQ ID NO: 7, and an ocular neovascularization inhibiting fragment thereof, which includes at least one of amino acid residue signature sequences HVGH (SEQ ID NO:10) and KMSAS (SEQ ID NO:11). A method for assaying the angiogenesis inhibiting activity of a composition is also provided.
Public/Granted literature
- US20090275643A1 Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis Public/Granted day:2009-11-05
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