Chemically modified oligonucleotides

Invention Grant

US08017763B2 Chemically modified oligonucleotides 有权

Title translation: 化学修饰的寡核苷酸

Patent Title: Chemically modified oligonucleotides
Patent Title (中): 化学修饰的寡核苷酸
Application No.: US12561529

Application Date: 2009-09-17
Publication No.: US08017763B2

Publication Date: 2011-09-13
Inventor: Muthiah Manoharan , Venkitasamy Kesavan , Kallanthottathil G. Rajeev
Applicant: Muthiah Manoharan , Venkitasamy Kesavan , Kallanthottathil G. Rajeev
Applicant Address: US MA Cambridge
Assignee: Alnylam Pharmaceuticals, Inc.
Current Assignee: Alnylam Pharmaceuticals, Inc.
Current Assignee Address: US MA Cambridge
Agency: LeClairRyan
Agent Jeffrey N. Townes
Main IPC: C07H21/04
IPC: C07H21/04 ; A61K31/70

Abstract:

This invention relates composition and methods for making and using chemically modified oligonucleotides agents for inhibiting gene expression.

Abstract(Chinese):

本发明涉及用于制备和使用化学修饰的寡核苷酸抑制基因表达的组合物和方法。

Public/Granted literature

Information query

Espacenet

IPC分类:

C	化学；冶金
C07	有机化学
C07H	糖类；及其衍生物；核苷；核苷酸；核酸（糖醛酸或糖质酸的衍生物入C07C、C07D；糖醛酸、糖质酸入C07C59/105，C07C59/285；氰醇类入C07C255/16；烯糖类入C07D；未知结构的化合物入C07G；多糖类，有关的衍生物入C08B；有关基因工程的DNA或RNA，载体，例如质粒，或它们的分离、制备或纯化入C12N15/00；制糖工业入C13）
C07H21/00	含有两个或多个单核苷酸单元的化合物，具有以核苷基的糖化物基团连接的单独的磷酸酯基或多磷酸酯基，例如核酸
C07H21/04	.有脱氧核糖基作为糖化物基团的