Invention Grant
- Patent Title: Process for preparing acyclic HCV protease inhibitors
- Patent Title (中): 制备无环HCV蛋白酶抑制剂的方法
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Application No.: US12355157Application Date: 2009-01-16
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Publication No.: US08017771B2Publication Date: 2011-09-13
- Inventor: Carl Alan Busacca , Rogelio Perez Frutos , Nizar Haddad , Suresh R. Kapadia , Jon Charles Lorenz , Anjan Saha , Chris Hugh Senanayake , Xudong Wei
- Applicant: Carl Alan Busacca , Rogelio Perez Frutos , Nizar Haddad , Suresh R. Kapadia , Jon Charles Lorenz , Anjan Saha , Chris Hugh Senanayake , Xudong Wei
- Applicant Address: DE Ingelheim am Rhein
- Assignee: Boehringer Ingelheim International GmbH
- Current Assignee: Boehringer Ingelheim International GmbH
- Current Assignee Address: DE Ingelheim am Rhein
- Agent Michael P. Morris; Philip I. Datlow
- Main IPC: C07D239/26
- IPC: C07D239/26 ; C07D241/04 ; C07D241/12 ; C07D231/12 ; C07D295/10 ; C07D277/24 ; C07C211/52
Abstract:
Disclosed are highly convergent processes for preparing compounds of formula (I), which compounds are potent active agents for the treatment of hepatitis C virus (HCV) infection: The disclosed processes use SNAr-type coupling reactions between peptidic compounds having a hydroxyproline moiety of the following formula: and halogenated or sulfonated bromoquinoline compounds.
Public/Granted literature
- US20090124809A1 PROCESS FOR PREPARING ACYCLIC HCV PROTEASE INHIBITORS Public/Granted day:2009-05-14
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