A gas sensor includes a substrate having a low thermal conductivity. Localized heating can be produced using a serpentined heater carried by the substrate. The low thermal conductivity of the substrate substantially confines the generated heat to a region local to the heater thereby reducing required power to operate the sensor. Multiple sensing elements can be deposited onto the substrate adjacent to respective heaters and relatively close together because of the thermal isolation provided by the substrate. In one embodiment, the sensor can include the ceramic substrate, the heater, catalytic material overlying the heater with a gas impermeable layer overlying, at least in part the catalytic material.