Reusable biopsy forceps having a handle located at the proximal end and an end jaw assembly located at the distal end. The handle and jaw assembly are connected by a flexible catheter tube. The handle includes a handle body, fluid inlet assembly, and catheter tube coupling. The jaw assembly consists of a housing composed of a first and second portion, which holds a pair of opposed jaws and a distal actuator. The distal actuator is connected to the handle by an operating cable located inside the catheter tube. The handle controls the jaws and contains a flush port to sterilize the interior of the catheter tube and the end jaw assembly. The reusable biopsy forceps may contain a locking mechanism that is attached to the arms of the biopsy forceps handle in order to aid in taking tissue samples.