Invention Grant
- Patent Title: Interferon alpha antibodies and their uses
- Patent Title (中): 干扰素α抗体及其用途
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Application No.: US12551250Application Date: 2009-08-31
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Publication No.: US08025882B2Publication Date: 2011-09-27
- Inventor: Alison J. Witte , Denise Williams , Josephine M. Cardarelli , David J. King , David B. Passmore
- Applicant: Alison J. Witte , Denise Williams , Josephine M. Cardarelli , David J. King , David B. Passmore
- Applicant Address: US NJ Princeton
- Assignee: Medarex, Inc.
- Current Assignee: Medarex, Inc.
- Current Assignee Address: US NJ Princeton
- Agency: Baker Botts L.L.P.
- Main IPC: A61K39/395
- IPC: A61K39/395
Abstract:
The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (IFN) alpha subtypes but do not substantially inhibit the biological activity of IFN alpha 21 or the biological activity of either IFN beta or IFN omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the biological activity of IFN alpha using the antibodies of the invention, as well as methods of treating disease or disorders mediated by IFN alpha, such as autoimmune diseases, transplant rejection and graft versus host disease, by administering the antibodies of the invention.
Public/Granted literature
- US20090324605A1 INTERFERON ALPHA ANTIBODIES AND THEIR USES Public/Granted day:2009-12-31
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