Invention Grant
US08026218B2 Bifunctional analgesic compounds for opioid receptor agonists and neurokinin-1 receptor antagonists
有权
用于阿片受体激动剂和神经激肽-1受体拮抗剂的双功能止痛化合物
- Patent Title: Bifunctional analgesic compounds for opioid receptor agonists and neurokinin-1 receptor antagonists
- Patent Title (中): 用于阿片受体激动剂和神经激肽-1受体拮抗剂的双功能止痛化合物
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Application No.: US11760445Application Date: 2007-06-08
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Publication No.: US08026218B2Publication Date: 2011-09-27
- Inventor: Victor Hruby , Padma Nair , Takashi Yamamoto
- Applicant: Victor Hruby , Padma Nair , Takashi Yamamoto
- Applicant Address: US AZ Tucson
- Assignee: The University of Arizona
- Current Assignee: The University of Arizona
- Current Assignee Address: US AZ Tucson
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Main IPC: A61K38/06
- IPC: A61K38/06 ; A61P23/00 ; A61P25/04
Abstract:
The present invention provides a novel chimeric compound comprising an agonist opioid receptor binding moiety at its N-terminus and an antagonist neurokinin-1 (NK1) receptor binding moiety at its C-terminus for producing analgesia, a pharmaceutical composition comprising the chimeric compound, a method of making the compound, and a method of treating pain using the novel chimeric compounds.
Public/Granted literature
- US20080039404A1 BIFUNCTIONAL ANALGESIC COMPOUNDS FOR OPIOID RECEPTOR AGONISTS AND NEUROKININ-1 RECEPTOR ANTAGONISTS Public/Granted day:2008-02-14
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