Invention Grant
- Patent Title: HIV replication inhibiting purine derivatives
- Patent Title (中): HIV复制抑制嘌呤衍生物
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Application No.: US10573364Application Date: 2004-09-21
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Publication No.: US08026245B2Publication Date: 2011-09-27
- Inventor: Paul Adriaan Jan Janssen , Paulus Joannes Lewi , Marc René de Jonge , Lucien Maria Henricus Koymans , Frederik Frans Desiré Daeyaert , Jan Heeres , Hendrik Maarten Vinkers , Ruben Gerardus George Leenders , Dirk Alfons Leo Vandenput
- Applicant: Paul Adriaan Jan Janssen , Frank Xavier Jozef Herwig Arts, legal representative , Paulus Joannes Lewi , Marc René de Jonge , Lucien Maria Henricus Koymans , Frederik Frans Desiré Daeyaert , Jan Heeres , Hendrik Maarten Vinkers , Ruben Gerardus George Leenders , Dirk Alfons Leo Vandenput
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica N.V.
- Current Assignee: Janssen Pharmaceutica N.V.
- Current Assignee Address: BE Beerse
- Agency: Patton Boggs LLP
- Priority: EPPCT/EP03/50659 20030925
- International Application: PCT/EP2004/052262 WO 20040921
- International Announcement: WO2005/028479 WO 20050331
- Main IPC: C07D473/16
- IPC: C07D473/16 ; C07D473/18 ; A61K31/52 ; A61K31/522 ; A61P31/18 ; C07D473/40

Abstract:
The present invention relates to the use of a compound of formula (I) for the manufacture of a medicament for the prevention or the treatment of HIV infection wherein the compound of formula (I) is a compound of formula a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein A and B each represents a radical of formula and wherein —C-D- represents a bivalent radical of formula —N═CH—NR17— (c-1); or —NR17—CH═N— (c-2); provided that when A represents a radical of formula (a) then B represents a radical of formula (b) and when A represents a radical of formula (b) then B represents a radical of formula (a).
Public/Granted literature
- US20060293330A1 Hiv replication inhibiting purine derivatives Public/Granted day:2006-12-28
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