Invention Grant
- Patent Title: Process for the large scale production of Stavudine
- Patent Title (中): 大量生产司他夫定的方法
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Application No.: US12094586Application Date: 2006-11-17
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Publication No.: US08026356B2Publication Date: 2011-09-27
- Inventor: Purna Chandra Ray , Jagan Mohana Chary Tummanapalli , Seeta Ramanjaneyulu Gorantla
- Applicant: Purna Chandra Ray , Jagan Mohana Chary Tummanapalli , Seeta Ramanjaneyulu Gorantla
- Applicant Address: IN Secunderabad
- Assignee: Matrix Laboratories, Ltd.
- Current Assignee: Matrix Laboratories, Ltd.
- Current Assignee Address: IN Secunderabad
- Agency: Knobbe, Martens, Olson & Bear, LLP
- Priority: IN1735/CHE/2005 20051128
- International Application: PCT/IN2006/000455 WO 20061117
- International Announcement: WO2007/060689 WO 20070531
- Main IPC: C07H19/00
- IPC: C07H19/00 ; C07H19/048 ; C07H5/04 ; C07H5/06 ; C08B37/00
Abstract:
The present invention provides a method for preparing pure Stavudine having purity more than 99.5% comprises: i) Converting 3′,5′-anhydrothymidine to crude Stavudine, ii) Converting crude Stavudine to stable solvates of Stavudine, iii) Desolvation of the solvates to give pure Stavudine. The present invention also disclosed novel solvates of Stavudine and conversion of novel Stavudine solvates to Stavudine.
Public/Granted literature
- US20080312428A1 Process for the Large Scale Production of Stavudine Public/Granted day:2008-12-18
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