The invention relates to a method and system that utilizes one or more cassettes or trays that hold medicaments for dispensing. In one embodiment, a method for dispensing includes receiving a signal at a medicament container authorizing the medicament container to dispense a medicament unit contained therein; unlocking an outlet port of the medicament container in response to the signal; dispensing the medicament unit through the outlet port in response to the signal; and locking the outlet port after the medicament unit is dispensed.