The cranium fixation device (1) includes a cranium clamp (2) having a first clamping element and a second clamping element (3, 4) and also a rod (5), with the rod (5) extending from the first clamping element and ending in an end portion (5d). The second clamping element (4) is displaceably arranged in the direction of extent (53) of the rod (5). A hand actuatable applicator (7) is provided and has a holding part (7a) and a thrust part (7b). The holding part (7a) and the thrust part (7b) are connected to one another via a connection part (7c). The end portion (5d) of the bar (5) is held by the holding part (7a) and the thrust part (7b) is arranged such that it can exert a force on the second clamping element (4) directed towards the first clamping element (3). The connection part (7c) extends partly spaced from the rod (5) such that a displacement of the connection part (7c) towards the rod (5) increases the distance between the holding part (7a) and the thrust part (7b) in order to thereby displace the second clamping part (4) via the thrust part (7b) acting thereon in the direction of the first clamping element (3).