Invention Grant
US08030033B2 Polymorphisms in ABCB1 associated with a lack of clinical response to medicaments
有权
ABCB1的多态性与药物缺乏临床反应有关
- Patent Title: Polymorphisms in ABCB1 associated with a lack of clinical response to medicaments
- Patent Title (中): ABCB1的多态性与药物缺乏临床反应有关
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Application No.: US11596177Application Date: 2005-05-12
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Publication No.: US08030033B2Publication Date: 2011-10-04
- Inventor: Manfred Uhr , Florian Holsboer , Elisabeth Binder , Bertram Mueller-Myhsok
- Applicant: Manfred Uhr , Florian Holsboer , Elisabeth Binder , Bertram Mueller-Myhsok
- Applicant Address: DE Munich
- Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenshaften e.V.
- Current Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenshaften e.V.
- Current Assignee Address: DE Munich
- Agency: Rothwell, Figg, Ernst & Manbeck, P.C.
- International Application: PCT/EP2005/005194 WO 20050512
- International Announcement: WO2005/108605 WO 20051117
- Main IPC: C12P19/34
- IPC: C12P19/34
Abstract:
The present invention relates to methods, compositions and kits for determining the prognosis of a clinical response in a human patient to a medicament which acts in the central nervous system and which is a substrate of the ABCB1 protein. Further, the invention relates to a combination of medicaments for the treatment of human patients having specific polymorphisms in the ABCB1 gene.
Public/Granted literature
- US20080064609A1 Polymorphisms in Abcb1 Associated with a Lack of Clinical Response to Medicaments Public/Granted day:2008-03-13
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