Invention Grant
US08030296B2 Oestrogen-17-sulphamates as inhibitors of steroid sulphatase
有权
雌激素-17-磺酰胺酸盐作为类固醇硫酸酯酶的抑制剂
- Patent Title: Oestrogen-17-sulphamates as inhibitors of steroid sulphatase
- Patent Title (中): 雌激素-17-磺酰胺酸盐作为类固醇硫酸酯酶的抑制剂
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Application No.: US11368367Application Date: 2006-03-03
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Publication No.: US08030296B2Publication Date: 2011-10-04
- Inventor: Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Hatem Hejaz , Bertrand Leblond , Matthew Paul Leese , Atul Purohit
- Applicant: Barry Victor Lloyd Potter , Michael John Reed , Lok Wai Lawrence Woo , Hatem Hejaz , Bertrand Leblond , Matthew Paul Leese , Atul Purohit
- Applicant Address: GB Slough Berkshire
- Assignee: Sterix Limited
- Current Assignee: Sterix Limited
- Current Assignee Address: GB Slough Berkshire
- Agency: Hunton & Williams LLP
- Priority: GB0020498.2 20000818
- Main IPC: A61K31/56
- IPC: A61K31/56 ; C07J1/00

Abstract:
There is provided a compound of Formula I wherein X is a ring system; R1 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein when X is a steroidal structure and both of R1 and R2 are sulphamate groups, the steroidal ring system (X) represents an oestrogen; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth. There is also provided a compound of Formula VIII wherein R2 is any one of a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; and wherein said compound is capable of inhibiting steroid sulphatase (STS) activity and/or is capable of acting as a modulator of cell cycling and/or as a modulator of apoptosis and/or as a modulator of cell growth.
Public/Granted literature
- US20060281719A1 Oestrogen-17-sulphamates as inhibitors of steroid sulphatase Public/Granted day:2006-12-14
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