Invention Grant
- Patent Title: Azabicyclic heterocycles as cannabinoid receptor modulators
- Patent Title (中): 氮杂环杂环作为大麻素受体调节剂
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Application No.: US12518707Application Date: 2007-12-13
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Publication No.: US08030306B2Publication Date: 2011-10-04
- Inventor: William R. Ewing , Yeheng Zhu , Richard B. Sulsky
- Applicant: William R. Ewing , Yeheng Zhu , Richard B. Sulsky
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Ying Wang
- International Application: PCT/US2007/087404 WO 20071213
- International Announcement: WO2008/076810 WO 20080626
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/5025 ; A61P3/00
Abstract:
The present application describes CB-1 inverse agonists according to Formula (I) and (Ia), pharmaceutical compositions comprising at least one compound according to Formula (I) or (Ia), and optionally one or more additional therapeutic agents and methods of treatment using the compounds according to Formula (I) or (Ia), both alone and in combination with one or more additional therapeutic agents. The preferred compounds have the general Formula (Ia), including all prodrugs, pharmaceutically acceptable salts and stereoisomer, thereof, wherein R1, R2, Ar1, Ar2 are defined herein.
Public/Granted literature
- US20100029656A1 AZABICYCLIC HETEROCYCLES AS CANNABINOID RECEPTOR MODULATORS Public/Granted day:2010-02-04
Information query
