Invention Grant
US08030307B2 Bicyclic, C5-substituted proline derivatives as inhibitors of the hepatitis C virus NS3 protease
有权
双环C5取代的脯氨酸衍生物作为丙型肝炎病毒NS3蛋白酶的抑制剂
- Patent Title: Bicyclic, C5-substituted proline derivatives as inhibitors of the hepatitis C virus NS3 protease
- Patent Title (中): 双环C5取代的脯氨酸衍生物作为丙型肝炎病毒NS3蛋白酶的抑制剂
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Application No.: US12324048Application Date: 2008-11-26
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Publication No.: US08030307B2Publication Date: 2011-10-04
- Inventor: Joel D. Moore , Yat Sun Or , Zhe Wang
- Applicant: Joel D. Moore , Yat Sun Or , Zhe Wang
- Applicant Address: US MA Watertown
- Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Elmore Patent Law Group, P.C.
- Agent Edgar W. Harlan; Carolyn S. Elmore
- Main IPC: A61K38/12
- IPC: A61K38/12 ; C07K5/12
Abstract:
The present invention relates to compounds of Formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising a compound of the present invention.
Public/Granted literature
- US20090180983A1 BICYCLIC, C5-SUBSTITUTED PROLINE DERIVATIVES AS INHIBITORS OF THE HEPATITIS C VIRUS NS3 PROTEASE Public/Granted day:2009-07-16
Information query
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