Invention Grant
US08030446B2 Mutant proline-and-arginine rich peptides and methods for using the same
有权
突变型富含脯氨酸和精氨酸的肽及其使用方法
- Patent Title: Mutant proline-and-arginine rich peptides and methods for using the same
- Patent Title (中): 突变型富含脯氨酸和精氨酸的肽及其使用方法
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Application No.: US11673790Application Date: 2007-02-12
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Publication No.: US08030446B2Publication Date: 2011-10-04
- Inventor: Sudha Veeraraghavan , Michael Simons
- Applicant: Sudha Veeraraghavan , Michael Simons
- Applicant Address: US NH Hanover US TX Austin
- Assignee: Trustees of Dartmouth College,Board of Regents University of Texas System
- Current Assignee: Trustees of Dartmouth College,Board of Regents University of Texas System
- Current Assignee Address: US NH Hanover US TX Austin
- Agency: Licata & Tyrrell, P.C.
- Main IPC: C07K7/00
- IPC: C07K7/00
Abstract:
The present invention relates to mutant proline-and-arginine rich (PR) peptides with defined structural characteristics for use in inhibiting mammalian 20S proteasome activity and modulating expression of genes regulating the NF-κB pathway. Mutant PR peptides of the present invention differ from wild-type PR peptides by having at least one to three amino acid substitutions, wherein at least one of the amino acid residues at position one, two or three of the mutant PR peptide is positively charged.
Public/Granted literature
- US20090068736A1 Mutant proline-and-arginine rich peptides and methods for using the same Public/Granted day:2009-03-12
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