Invention Grant
US08030447B2 Substrate peptide sequences for plague plasminogen activator and uses thereof
有权
用于瘟疫纤溶酶原激活物的底物肽序列及其用途
- Patent Title: Substrate peptide sequences for plague plasminogen activator and uses thereof
- Patent Title (中): 用于瘟疫纤溶酶原激活物的底物肽序列及其用途
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Application No.: US11901978Application Date: 2007-09-20
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Publication No.: US08030447B2Publication Date: 2011-10-04
- Inventor: Vladimir L. Motin , Sadhana Chauhan , Scott R. Gilbertson , Anton Agarkov , Pedro Lory
- Applicant: Vladimir L. Motin , Sadhana Chauhan , Scott R. Gilbertson , Anton Agarkov , Pedro Lory
- Applicant Address: US TX Austin
- Assignee: The Board of Regents of the University of Texas System
- Current Assignee: The Board of Regents of the University of Texas System
- Current Assignee Address: US TX Austin
- Agent Benjamin Aaron Adler
- Main IPC: C07K7/06
- IPC: C07K7/06
Abstract:
The present invention is directed to peptide sequences that were identified from combinatorial libraries and could serve as substrates of plague plasminogen activator (Pla). Another aspect of the present invention is drawn to peptides derived from the substrates for Pla as a result of chemical modifications leading to specific inactivation of the proteolytic activity of Pla. Additionally, the present invention is directed to the use of the substrates identified herein in the detection of bacteria expressing omptin family of proteases which includes Y. pestis. Furthermore, the present invention is also directed to the use of the inhibitors identified herein in the prevention and treatment of infection caused by these bacteria.
Public/Granted literature
- US20090069248A1 Substrate peptide sequences for plague plasminogen activator and uses thereof Public/Granted day:2009-03-12
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