Invention Grant
- Patent Title: 5′-modified bicyclic nucleic acid analogs
- Patent Title (中): 5'-修饰的双环核酸类似物
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Application No.: US12751706Application Date: 2010-03-31
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Publication No.: US08030467B2Publication Date: 2011-10-04
- Inventor: Punit P. Seth , Eric E. Swayze , Balkrishen Bhat
- Applicant: Punit P. Seth , Eric E. Swayze , Balkrishen Bhat
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Jones Day
- Main IPC: C07H21/02
- IPC: C07H21/02 ; C07H21/04

Abstract:
The present invention provides 5′-modified bicyclic nucleoside analogs and oligomeric compounds comprising at least one of these nucleoside analogs. In preferred embodiments the nucleoside analogs have either (R) or (S)-chirality at the 5′-carbon. These bicyclic nucleoside analogs are useful for enhancing properties of oligomeric compounds including for example enhanced nuclease resistance.
Public/Granted literature
- US20100184966A1 5'-MODIFIED BICYCLIC NUCLEIC ACID ANALOGS Public/Granted day:2010-07-22
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