A computer hot-plug structure allows a hard disk to be connected to a computer in a hot-plug fashion. The computer has a casing and a plurality of side panels surrounding various sides of the casing. Each side panel has a thread-hole and a hood covering the thread-hole. The hood has a top portion and two flanks at two ends of the top portion to form a housing space for plugging and unplugging of the hard disk. The housing space has one end formed an insertion slot to receive the hard disk and a hot-plug connector at another end. The hot-plug connector has a first connection port connected to the hard disk and a second connection port electrically connected to the computer through a transmission line passing through the thread-hole. Thus the hard disk is held on the outer side of the computer to save the interior space of the computer.