A hybrid annotation and publication system can access content in a scalable manner from databases, allowing for its editing and publication via wiki-style programs, while at the same time allowing for peer-review of such content via peer-review programs. This system balances the wiki-style programs, the peer-review programs, and any database store accesses in a manner appropriate to the need at hand according to various heuristics. For instance, the system can be accessed via a web browser, and data provided from various databases can be edited. Such data can be stored in the system in a hierarchical manner. Once the content is annotated, it can be reviewed (at various levels, ranging from expert to novice). Upon review, such content can be published using the wiki programs, so that the content is ready for public and/or private consumption.