Security components of managed computers are configured using inoculation data. Inoculation data can be retrieved from an inoculation data provider. The inoculation data provider analyzes unauthorized software applications to develop inoculation data. The inoculation data configures the security component to deny access to resources to unauthorized software applications. Inoculation data can be embedded into a script, which is distributed via a management protocol to one or more managed computers from a management computer. Resources can include files, storage paths, memory, registry keys, processor priority, services, dynamic link libraries, archives, browser cookies, and/or ActiveX controls, Java applets, or classes thereof.