Invention Grant
US08048673B2 Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
有权
使用脂肪组织来源的基质细胞进行软骨细胞分化和软骨修复
- Patent Title: Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
- Patent Title (中): 使用脂肪组织来源的基质细胞进行软骨细胞分化和软骨修复
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Application No.: US11408381Application Date: 2006-04-21
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Publication No.: US08048673B2Publication Date: 2011-11-01
- Inventor: Yuan-Di C. Halvorsen , William O. Wilkison , Jeffrey M. Gimble
- Applicant: Yuan-Di C. Halvorsen , William O. Wilkison , Jeffrey M. Gimble
- Applicant Address: US NC Durham
- Assignee: Artecel Sciences, Inc.
- Current Assignee: Artecel Sciences, Inc.
- Current Assignee Address: US NC Durham
- Agency: Seed IP Law Group PLLC
- Main IPC: C12N5/02
- IPC: C12N5/02
Abstract:
Methods and compositions for directing adipose-derived stromal cells cultivated in vitro to differentiate into cells of the chondrocyte lineage are disclosed. The invention further provides a variety of chondroinductive agents which can be used singly or in combination with other nutrient components to induce chondrogenesis in adipose-derived stromal cells either in cultivating monolayers or in a biocompatible lattice or matrix in a three-dimensional configuration. Use of the differentiated chondrocytes for the therapeutic treatment of a number of human conditions and diseases including repair of cartilage in vivo is disclosed.
Public/Granted literature
- US20060188985A1 Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair Public/Granted day:2006-08-24
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