Invention Grant
US08048850B2 Covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins and methods of use
有权
青蒿素相关内过氧化物和携带铁蛋白之间的共价缀合物和使用方法
- Patent Title: Covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins and methods of use
- Patent Title (中): 青蒿素相关内过氧化物和携带铁蛋白之间的共价缀合物和使用方法
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Application No.: US10457078Application Date: 2003-06-06
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Publication No.: US08048850B2Publication Date: 2011-11-01
- Inventor: Henry C. Lai , Tomikazu Sasaki , Narendra P. Singh
- Applicant: Henry C. Lai , Tomikazu Sasaki , Narendra P. Singh
- Applicant Address: US WA Seattle
- Assignee: University of Washington
- Current Assignee: University of Washington
- Current Assignee Address: US WA Seattle
- Agency: Christensen O'Connor Johnson Kindness PLLC
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A61K47/00 ; A61K43/00 ; A61K35/00 ; C07D323/00 ; A01N43/02
Abstract:
In one aspect, the invention provides covalent conjugates between artemisinin-related endoperoxides and iron-carrying proteins. In some embodiments, the covalent conjugates comprise artelinate and holotransferrin. In another aspect, the invention provides methods for administering the covalent conjugates of the invention to treat cancer and infections by pathogens that bind iron-carrying proteins.
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