Invention Grant
US08048884B2 Substituted piperazinyl pyrazines and pyridines as 5-HT7 receptor antagonists
有权
取代的哌嗪基吡嗪和吡啶作为5-HT 7受体拮抗剂
- Patent Title: Substituted piperazinyl pyrazines and pyridines as 5-HT7 receptor antagonists
- Patent Title (中): 取代的哌嗪基吡嗪和吡啶作为5-HT 7受体拮抗剂
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Application No.: US12447546Application Date: 2008-08-19
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Publication No.: US08048884B2Publication Date: 2011-11-01
- Inventor: Michael Philip Cohen , Sarah Lynne Hellman , Sean Patrick Hollinshead , Sandra Ann Filla , Michael Wade Tidwell
- Applicant: Michael Philip Cohen , Sarah Lynne Hellman , Sean Patrick Hollinshead , Sandra Ann Filla , Michael Wade Tidwell
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent R. Craig Tucker
- International Application: PCT/US2008/073543 WO 20080819
- International Announcement: WO2009/029439 WO 20090305
- Main IPC: A01N43/58
- IPC: A01N43/58 ; A01N43/60 ; A61K31/50 ; A61K31/495 ; A61K31/497
Abstract:
The present invention provides selective 5-HT7 receptor antagonist compounds of Formula I and their use in the treatment of migraine: where A is —C(H)═ or —N═; m is 0, 1 or 2; R1 is optionally substituted phenyl, optionally substituted pyrazol-4-yl; optionally substituted imidazolyl, optionally substituted pyridyl, or thienyl; R2 is hydrogen or methyl; and R3 and R4 are as defined herein.
Public/Granted literature
- US20100075976A1 SUBSTITUTED PIPERAZINYL PYRAZINES AND PYRIDINES AS 5-HT7 RECEPTOR ANTAGONISTS Public/Granted day:2010-03-25
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